Where there's smoke there's not necessarily fire

Where there's smoke, there's fire.

Where there is smoke, there is fire.

The ankle-brachial index (ABI), a ratio of systolic blood pressure measured at the ankle and the brachial artery, is a simple noninvasive screening test used to diagnose peripheral arterial disease (PAD). PAD affects over 12 million people in the United States and its prevalence increases with increasing age (1,2). Patients with an abnormal ABI, defined as 0.90 or 1.40, are at increased risk of...

Mitochondrial DNA damage, oxidative stress, and atherosclerosis: where there is smoke there is not always fire.

NAD(P)H oxidase: where there's smoke, there's fire.

IN INDUSTRIALIZED NATIONS such as the United States, tobacco represents the leading cause of deaths, with a majority of these being associated with cardiovascular disease, rather than cancer (2, 20). The vasculature develops an inflammatory and thrombogenic phenotype in response to many cardiovascular risk factors, including hypertension, hypercholesterolemia, and smoking, and these alterations...

Soluble P-selectin is the smoke, not the fire.

intermediary drives ibrutinib resistance, whereas presence of a complex karyotype and Del17p are predictive of progression while on ibrutinib. Additional work in larger cohorts of samples may be required to address whether USP7 inhibition would be sufficient to target disease in this subgroup of patients. In conclusion, despite unresolved queries, this study identifies that USP7 is an attractiv...